CAS number: 1300–73–8 (mixed isomers)
NIOSH REL: 2 ppm (10 mg/m3) TWA [skin]
Current OSHA PEL: 5 ppm (25 mg/m3) TWA [skin]
1989 OSHA PEL: 2 ppm (10 mg/m3) TWA [skin]
1993-1994 ACGIH TLV: 0.5 ppm (2.5 mg/m3) TWA [skin], A2
Description of substance: Pale-yellow to brown liquid with a weak, aromatic, amine-like odor.
LEL: . . 1.0% (10% LEL, 1,000 ppm)
Original (SCP) IDLH: 150 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 7-hour LC50 of 149 ppm [von Oettingen et al. 1947 cited by ACGIH 1971].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derived value |
| Mice (2,4-) | von Oettingen et al. 1947 | 149 | —– | 7 hr | 358 ppm (2.4) | 36 ppm |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
| Rabbit | Deichmann & Gerarde 1969 | oral | —– | 600 | 833 ppm | 83 ppm |
| Rat | Treon et al. 1949 | oral | —– | 610 | 847 ppm | 85 ppm |
| Rat (2,3-) | Vernot et al. 1977 | oral | —– | 930 | 1,292 ppm | 129 ppm |
| Mouse (2,3-) | Vernot et al. 1977 | oral | —– | 1,070 | 1,486 ppm | 149 ppm |
| Rat (2,4-) | Vernot et al. 1977 | oral | —– | 470 | 653 ppm | 65 ppm |
| Mouse (2,4-) | Vernot et al. 1977 | oral | —– | 250 | 347 ppm | 35 ppm |
| Rat (2,4-) | Lindstrom et al. 1969 | oral | —– | 1,259 | 1,749 ppm | 175 ppm |
| Rat (2,5-) | Vernot et al. 1977 | oral | —– | 1,300 | 1,806 ppm | 181 ppm |
| Mouse (2,5-) | Vernot et al. 1977 | oral | —– | 840 | 1,167 ppm | 117 ppm |
| Rat (2,6-) | Vernot et al. 1977 | oral | —– | 1,230 | 1,708 ppm | 171 ppm |
| Mouse (2,6-) | Vernot et al. 1977 | oral | —– | 710 | 986 ppm | 99 ppm |
| Rat (2,6-) | Short et al. 1983 | oral | —– | 1,050 | 1,458 ppm | 146 ppm |
| Rat (3,4-) | Vernot et al. 1977 | oral | —– | 810 | 1,125 ppm | 113 ppm |
| Mouse (3,4-) | Vernot et al. 1977 | oral | —– | 710 | 986 ppm | 99 ppm |
| Rat (3,5-) | Vernot et al. 1977 | oral | —– | 710 | 986 ppm | 99 ppm |
| Mouse (3,5-) | Vernot et al. 1977 | oral | —– | 420 | 583 ppm | 58 ppm |
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 50 ppmBasis for revised IDLH: The revised IDLH for xylidine is 50 ppm based on acute toxicity data in animals [Deichmann and Gerarde 1969; Treon et al. 1949; Vernot et al. 1977; von Oettingen et al. 1947]. This may be a conservative value due to the lack of relevant acute toxicity data for workers. |
Provided By:
https://www.cdc.gov/niosh/idlh/1300738.html
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